Abstract | BACKGROUND: METHODS: Ovid MEDLINE, Embase and Cochrane Central Register of Controlled Trials were searched from inception to October 2021 for randomized controlled trials investigating the efficacy of corticosteroids in hand osteoarthritis. Two authors independently screened records, extracted data, and assessed risk of bias using the RoB 2 tool. Standardized mean difference (SMD) or mean difference (MD) was calculated, and random-effects meta-analyses were performed. RESULTS: Of 13 included trials, 3 examined oral corticosteroids and clinical outcomes in any hand joints, 9 examined intra-articular injection of corticosteroids and clinical outcomes at the first carpometacarpal joint and one in the interphalangeal joints. In meta-analysis, oral corticosteroids reduced pain (SMD -0.53, 95% CI -0.79 to -0.28) and improved stiffness (MD -5.03, 95% CI -9.91 to -0.15; Australian Canadian Osteoarthritis Hand Index stiffness subscale) and function (SMD -0.37, 95% CI -0.63 to -0.12) at 4-6 weeks. However, there was no significant persistent effect on pain and function at 3 months which was 6-8 weeks after study medication was stopped. There was no significant effect of intra-articular corticosteroids on pain or function at 4-6 weeks or over 3-12 months in first carpometacarpal osteoarthritis. Two trials evaluated joint structure at 4-6 weeks: one study showed oral corticosteroids reduced synovial thickening, neither showed an effect on synovitis. CONCLUSIONS:
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Authors | Mahnuma Mahfuz Estee, Flavia M Cicuttini, Matthew J Page, Anant D Butala, Anita E Wluka, Sultana Monira Hussain, Yuanyuan Wang |
Journal | BMC musculoskeletal disorders
(BMC Musculoskelet Disord)
Vol. 23
Issue 1
Pg. 665
(Jul 13 2022)
ISSN: 1471-2474 [Electronic] England |
PMID | 35831847
(Publication Type: Journal Article, Meta-Analysis, Systematic Review)
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Copyright | © 2022. The Author(s). |
Chemical References |
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Topics |
- Adrenal Cortex Hormones
(therapeutic use)
- Australia
- Canada
- Humans
- Osteoarthritis, Knee
(therapy)
- Pain
(drug therapy)
- Randomized Controlled Trials as Topic
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