Positive intravenous secretin test in patients with achlorhydria-related hypergastrinemia.

Abstract

The intravenous secretin test is widely used to distinguish gastrinoma (Zollinger-Ellison syndrome) from other causes of fasting hypergastrinemia. We report 2 patients with fasting hypergastrinemia and a rise of greater than 200 pg/ml in serum gastrin concentration after intravenous injection of 2 CU/kg body wt of pure natural secretin. Both patients had pentagastrin-fast achlorhydria. Thus, the intravenous secretin test may be positive in patients with achlorhydria-related hypergastrinemia. Gastric acid secretion should be measured in hypergastrinemic patients before embarking on a secretin test.

• Authors: M Feldman, L R Schiller, J H Walsh, J S Fordtran, C T Richardson
• Journal: Gastroenterology (Gastroenterology) Vol. 93 Issue 1 Pg. 59-62 (Jul 1987) ISSN: 0016-5085 [Print] United States
• PMID: 3582916 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Gastrins
• Secretin

Topics

• Achlorhydria (blood)
• Cross Reactions
• False Positive Reactions
• Female
• Gastrins (blood)
• Humans
• Middle Aged
• Secretin
• Zollinger-Ellison Syndrome (blood, diagnosis)