Nutritional vitamin D is efficacious for reducing intact parathyroid hormone in chronic kidney disease, a prospective interventional study.

Abstract

OBJECTIVE:

To see the efficacy of oral cholecalciferol administered to chronic kidney disease patients with vitamin D deficiency.

Methods:

The prospective interventional study was conducted at the Indus Hospital, Karachi, from January 11, 2017, to January 10, 2018, and comprised diagnosed pre-dialysis chronic kidney disease patients of either gender aged >14 years having vitamin D deficiency. Oral vitamin D 50,000IU was given weekly to those who had severe deficiency <10ng/ml, and every other week to those with less severe 10-25ng/ml deficiency for 3 months. Improvement in vitamin D level was checked along with other chronic kidney disease markers every month over the 3-month period. Data was analysed using SPSS 24.

RESULTS:

Of the 186 patients enrolled, 129(%) completed the study; 76(58.5%) males and 53(40.8%) females. Overall, 105(81.4%) patients achieved normal vitamin D levels after 3 months of treatment. Significant negative but weak correlation of phosphate, creatinine and intact parathyroid hormone levels was found with vitamin D (p<0.05). Significant positive but weak correlation was found between albumin and vitamin D levels (p<0.05).

Conclusion:

Significant efficacy of oral vitamin D in chronic kidney disease patients was seen.

• Authors: Shoukat Memon, Ashar Alam, Salman Imtiaz
• Journal: JPMA. The Journal of the Pakistan Medical Association (J Pak Med Assoc) Vol. 72 Issue 6 Pg. 1068-1074 (Jun 2022) ISSN: 0030-9982 [Print] Pakistan
• PMID: 35751311 (Publication Type: Journal Article)

Chemical References

• Parathyroid Hormone
• Vitamins
• Vitamin D
• Cholecalciferol

Topics

• Cholecalciferol (therapeutic use)
• Female
• Humans
• Male
• Parathyroid Hormone
• Prospective Studies
• Renal Insufficiency, Chronic (complications, therapy)
• Vitamin D (therapeutic use)
• Vitamin D Deficiency (complications, drug therapy)
• Vitamins (therapeutic use)