Abstract | PURPOSE: MATERIALS AND METHODS: All patients evaluated in the study received at least 1 dose of HAL at the time of office cystoscopy, and a subset of these patients (n = 103, 33.2%) received a second dose a few weeks later at the time of TURBT. Adverse events (AEs) were recorded, and the safety of repeat use of HAL was determined by comparing the proportion of patients with AEs considered causally related to HAL in the surveillance examination compared to the OR examination. Association between categorical variables was tested using Fisher's Exact Test, and a P < 0.05 was considered statistically significant. RESULTS: HAL-related AEs were experienced by 6 patients (2.2%) during surveillance cystoscopy and 3 patients (3.4%) following TURBT (P = 0.76); 181 patients (59.5%) had prior exposure to HAL before enrolling in the study with no difference in the number of AEs when comparing prior exposure to HAL to no prior exposure (P = 0.76). Of the patients who previously received intravesical therapy, 8 (2.9%) had at least 1 AE during surveillance compared to 3 (9.7%) who had no prior intravesical therapy (P = 0.09). CONCLUSIONS: Repeat use of HAL is safe even when administered within a few weeks of receiving a dose of intravesical therapy.
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Authors | Kamal S Pohar, Sanjay Patel, Yair Lotan, Edouard Trabulsi, Michael Woods, Tracy Downs, William C Huang, Jeffrey Jones, Jennifer Taylor, Michael O'Donnell, Trinity J Bivalacqua, Joel DeCastro, Gary Steinberg, Ashish M Kamat, Matthew J Resnick, Badrinath Konety, Mark Schoenberg, J Stephen Jones, Siamak Daneshmand, Flexible Blue Light Study Group Collaborators |
Journal | Urologic oncology
(Urol Oncol)
Vol. 40
Issue 8
Pg. 382.e1-382.e6
(08 2022)
ISSN: 1873-2496 [Electronic] United States |
PMID | 35750559
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2022 Elsevier Inc. All rights reserved. |
Chemical References |
- Aminolevulinic Acid
- 5-aminolevulinic acid hexyl ester
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Topics |
- Aminolevulinic Acid
(adverse effects, analogs & derivatives)
- Cystectomy
(methods)
- Cystoscopy
(methods)
- Humans
- Urinary Bladder Neoplasms
(drug therapy, pathology, surgery)
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