Abstract | OBJECTIVE: DATA SOURCES: Literature review was conducted using MEDLINE (PubMed), EMBASE, and ClinicalTrials.gov for articles published between January 2010 and May 2022. STUDY SELECTION AND DATA EXTRACTION: Articles in English discussing tralokinumab in AD were included. DATA SYNTHESIS: In one phase 2 trial, more subjects treated with tralokinumab 150 and 300 mg achieved an Investigator's Global Assessment ( IGA) of 0/1 with minimum ≥2 point IGA reduction (23%), versus placebo (11.8%, P = 0.10). During 2 phase 3 trials, more subjects treated with tralokinumab achieved IGA success (ECZTRA 1: 15.8% and ECZTRA 2: 22.2%), versus placebo (7.1% and 10.9%, respectively; P = 0.002 and P < 0.001). During one phase 3 trial, in conjunction with topical corticosteroids (TCS), more subjects treated with tralokinumab 300 mg achieved IGA success (ECZTRA 3: 38.9%), versus placebo (26.2%, P = 0.015). During another phase 3 trial in subjects with resistance or contraindication to oral cyclosporine, more subjects treated with tralokinumab 300 mg achieved an Eczema Area Severity Index 75 (64.2%), versus placebo (50.5%, P = 0.018). RELEVANCE TO PATIENT CARE AND CLINICAL PRACTICE: CONCLUSIONS:
Tralokinumab is an efficacious and safe systemic treatment for moderate-to-severe AD.
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Authors | Rohan Singh, Alexandra Taylor, Milaan A Shah, Lindsay C Strowd, Steven R Feldman |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 57
Issue 3
Pg. 333-340
(03 2023)
ISSN: 1542-6270 [Electronic] United States |
PMID | 35730479
(Publication Type: Journal Article, Review)
|
Chemical References |
- tralokinumab
- Interleukin-13
- Glucocorticoids
- Cyclosporine
- Dermatologic Agents
- Immunoglobulin A
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Topics |
- Humans
- Dermatitis, Atopic
(drug therapy, complications, pathology)
- Interleukin-13
(therapeutic use)
- Treatment Outcome
- Double-Blind Method
- Severity of Illness Index
- Glucocorticoids
(therapeutic use)
- Cyclosporine
(therapeutic use)
- Dermatologic Agents
(therapeutic use)
- Immunoglobulin A
(therapeutic use)
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