Polyphosphate in Chronic Wound Healing: Restoration of Impaired Metabolic Energy State.

Abstract

Many pathological conditions are characterized by a deficiency of metabolic energy. A prominent example is nonhealing or difficult-to-heal chronic wounds. Because of their unique ability to serve as a source of metabolic energy, inorganic polyphosphates (polyP) offer the opportunity to develop novel strategies to treat such wounds. The basis is the generation of ATP from the polymer through the joint action of two extracellular or plasma membrane-bound enzymes alkaline phosphatase and adenylate kinase, which enable the transfer of energy-rich phosphate from polyP to AMP with the formation of ADP and finally ATP. Building on these findings, it was possible to develop novel regeneratively active materials for wound therapy, which have already been successfully evaluated in first studies on patients.

• Authors: Xiaohong Wang, Hadrian Schepler, Meik Neufurth, Shunfeng Wang, Heinz C Schröder, Werner E G Müller
• Journal: Progress in molecular and subcellular biology (Prog Mol Subcell Biol) Vol. 61 Pg. 51-82 ( 2022) ISSN: 0079-6484 [Print] United States
• PMID: 35697937 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG.

Chemical References

• Polyphosphates
• Adenosine Triphosphate
• Adenylate Kinase
• Alkaline Phosphatase

Topics

• Adenosine Triphosphate (metabolism)
• Adenylate Kinase (metabolism)
• Alkaline Phosphatase (metabolism)
• Humans
• Polyphosphates (metabolism, therapeutic use)
• Wound Healing