Abstract | OBJECTIVES: Ductal epithelial changes (lympho-epithelial lesions-LEL) in prostatic chronic inflammation (CI) are not well studied so far. AIM: to investigate LEL immediately adjacent to prostatic CI. METHODS: RESULTS: LEL was identified in all types of prostatic specimens and in all types of prostatic CI: in 70.9% of patients with HP; in 100% of cases with NSGP; in 68.7% and in 80% adjacent to BPH and PCa respectively. Statistical analysis showed a significant correlation of the presence of LEL with HG CI (p<0.001). LEL showed strong membranous PD-L1 expression. CONCLUSIONS: The study presents the first attempt to examine LEL in inflammatory human prostate. PD-L1 positive LEL have no diagnostic organ specificity, although they are a constant histological finding in HG prostatic CI. LEL, inducible after birth by CI, are an integral part of prostate-associated lymphoid tissue (PALT) and of the inflammatory prostatic microenvironment.
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Authors | Dorian Dikov, Maria Koleva, Kiril Simitchiev, Marin Baltov, Victoria Sarafian |
Journal | Histology and histopathology
(Histol Histopathol)
Vol. 37
Issue 8
Pg. 749-755
(Aug 2022)
ISSN: 1699-5848 [Electronic] Spain |
PMID | 35670049
(Publication Type: Journal Article)
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Copyright | ©The Author(s) 2022. Open Access. This article is licensed under a Creative Commons CC-BY International License. |
Chemical References |
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Topics |
- B7-H1 Antigen
- Humans
- Inflammation
(pathology)
- Male
- Prostate
(pathology)
- Prostatic Hyperplasia
(pathology)
- Prostatic Neoplasms
(pathology)
- Prostatitis
(diagnosis, metabolism, pathology)
- Tumor Microenvironment
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