The preventive and
therapeutic effects of 2-(10,11-dihydro-10-oxodibenzo [b,f]thiepin-2-yl)
propionic acid (CN-100) on local and systemic changes of rats with
adjuvant arthritis being used frequently as experimental model of
rheumatoid arthritis were investigated in comparison with those of reference drugs,
indometacin and
pranoprofen. Preventively and therapeutically
CN-100 showed potent inhibitory effects on adjuvant primary
inflammation and secondary lesion.
CN-100 also exerted an evident preventive effect on destruction of foot bone, improved the changes in organ weight, and stimulated
weight gain. These effects were dose-dependent, and the effects at 5.0 mg/kg were almost the same as those of
indometacin and
pranoprofen at 1.25 and 2.5 mg/kg, respectively. The mode of action of
CN-100 resembled that of reference compounds. Although
CN-100 improved the change in
albumin/
globulin ratio, which was a parameter of systemic inflammatory reactions, the effect was more remarkable in therapeutic administration than in preventive one. This suggests that
CN-100 is suitable for clinical application.