Evaluation of pathological complete response after neoadjuvant systemic treatment of invasive breast cancer using diffusion-weighted imaging compared with dynamic contrast-enhanced based kinetic analysis.

Abstract

PURPOSE:

This study compared the performance of diffusion-weighted imaging (DWI) to dynamic contrast-enhanced (DCE)-MRI for diagnosing pathological complete response (pCR) before surgery.

METHOD:

Overall, 133 lesions from 133 patients who underwent pre-surgical MRI evaluation after neoadjuvant systemic treatment were included. Two readers blinded to the pathological diagnosis evaluated the images. MR images were obtained using a routine protocol sequence that included DWI and DCE-MRI. DWI of the target lesion was scored using a three-point scale. Kinetic patterns of lesions on DCE-MRI were scored using a four-point scale. The capacities of DWI and kinetic parameters for discriminating pCR and non-pCR were assessed via receiver operating characteristic (ROC) analysis.

RESULTS:

For DWI scores, ROC analysis showed areas under the ROC curve (AUCs) of 0.84 (95% confidence interval: 0.77-0.90) and 0.85 (0.77-0.90) for readers 1 and 2, respectively; corresponding AUCs of kinetic scores were 0.89 (0.82-0.94) and 0.88 (0.81-0.93). Among the triple-negative subtype, the AUCs of DWI scores were 0.84 (0.70-0.93) and 0.88 (0.75-0.96) for readers 1 and 2, respectively; corresponding AUCs of kinetic scores were 0.94 (0.83-0.99) and 0.93 (0.82-0.99). Among the luminal subtype, the AUCs of DWI scores were 0.85 (0.71-0.94) and 0.82 (0.68-0.92) for readers 1 and 2, respectively; corresponding AUCs of kinetic scores were 0.82 (0.68-0.92) and 0.72 (0.56-0.85).

CONCLUSIONS:

Our DWI-based visual score and kinetic score showed similar diagnostic performances. Both DWI and kinetic scores tended to perform better in predicting pCR for the triple-negative subtype.

• Authors: Rie Ota, Masako Kataoka, Mami Iima, Maya Honda, Akane Ohashi, Ayami Ohno Kishimoto, Kanae Kawai Miyake, Yosuke Yamada, Yasuhide Takeuchi, Masakazu Toi, Yuji Nakamoto
• Journal: European journal of radiology (Eur J Radiol) Vol. 154 Pg. 110372 (Sep 2022) ISSN: 1872-7727 [Electronic] Ireland
• PMID: 35667297 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Elsevier B.V. All rights reserved.

Chemical References

• Contrast Media

Topics

• Breast Neoplasms (diagnostic imaging, drug therapy, surgery)
• Contrast Media
• Diffusion Magnetic Resonance Imaging (methods)
• Female
• Humans
• Kinetics
• Magnetic Resonance Imaging (methods)
• Neoadjuvant Therapy (methods)
• Retrospective Studies