δ2-Opioid Receptors as a Target in Designing New Cardioprotective Drugs: the Role of Protein Kinase C, AMPK, and Sarcolemmal KATP Channels.

Abstract

In rats anesthetized with α-chloralose, coronary artery occlusion (45 min) and reperfusion (120 min) were modeled. The selective δ2-opioid receptor agonist deltorphin II was administered 5 min before reperfusion. Protein kinase C inhibitor chelerythrine, AMP-activated protein kinase inhibitor compound C, and ATP-sensitive K+ channel blockers glibenclamide, 5-hydroxydecanoate, and HMR 1098 were administered 10 min before reperfusion. It was found that the infarct-limiting effect of deltorphin II is associated with activation of protein kinase C and opening of sarcolemmal ATP-sensitive K+ channel.

• Authors: A V Mukhomedzyanov, S V Popov, L N Maslov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 173 Issue 1 Pg. 33-36 (May 2022) ISSN: 1573-8221 [Electronic] United States
• PMID: 35622247 (Publication Type: Journal Article)
• Copyright: © 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Chemical References

• KATP Channels
• Receptors, Opioid
• Adenosine Triphosphate
• Protein Kinase C
• AMP-Activated Protein Kinases

Topics

• AMP-Activated Protein Kinases (metabolism)
• Adenosine Triphosphate
• Animals
• KATP Channels (metabolism)
• Myocardial Reperfusion Injury (metabolism)
• Protein Kinase C (genetics, metabolism)
• Rats
• Receptors, Opioid (metabolism)