Abstract | PURPOSE: In the tazemetostat E7438-G000-101 trial of relapsed/refractory (R/R) follicular lymphoma (FL), apparent superior efficacy was suggested for mutant-type (MT) EZH2 versus wild-type (WT) status. However, clinical disparities might have contributed to this conclusion. This study aimed to estimate outcomes after minimizing differences in baseline characteristics. METHODS: Propensity scores for each participant with WT (n = 54) and MT (n = 45) status were generated based on the likelihood of being selected given their baseline characteristics. Participants were matched using a 1:1 nearest-neighbor approach. RESULTS: The propensity-matched sample included 56 participants (28 WT, 28 MT). Objective response rates (95% confidence interval [CI]) were 35% (22-48) in WT and 69% (55-83) in MT prior to matching and 50% (31-69) in WT and 71% (54-88) in MT after matching. Median progression-free survival values (95% CI) were 11.1 (5.4-16.7) in WT and 13.8 months (11.1-22.1) in MT prior to matching and 14.3 (11.1-∞]) and 14.8 months (10.7-∞]) in WT and MT matched groups, respectively. CONCLUSIONS: This analysis suggests that efficacy outcomes for tazemetostat observed in participants with WT EZH2 R/R FL may have been similar to those in participants with MT had the 2 cohorts been more closely matched.
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Authors | David G Proudman, Deepshekhar Gupta, Dave Nellesen, Jay Yang, Beth A Kamp, Khalid Mamlouk, Bruce D Cheson |
Journal | Oncotarget
(Oncotarget)
Vol. 13
Pg. 677-683
( 2022)
ISSN: 1949-2553 [Electronic] United States |
PMID | 35574216
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright: © 2022 Proudman et al. |
Chemical References |
- Benzamides
- Biphenyl Compounds
- Morpholines
- Pyridones
- tazemetostat
|
Topics |
- Benzamides
- Biphenyl Compounds
- Humans
- Lymphoma, Follicular
(drug therapy, genetics)
- Morpholines
- Propensity Score
- Pyridones
|