HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Nicotinic acetylcholine receptor stimulation: A new approach for stimulating tear secretion in dry eye disease.

Abstract
Tear secretion is regulated by the lacrimal functional unit consisting of afferent and efferent nerve innervation. The afferent arm consists of trigeminal nociceptors on the ocular surface and nasal mucosa. When stimulated by agonists, nicotinic acetylcholine receptors on nerve endings in the nose initiate a reflex arc resulting in instantaneous tear secretion. Pharmacologic nasal neural stimulation to increase endogenous tear production is a novel approach to treating dry eye disease.
AuthorsStephen C Pflugfelder, Austin Cao, Anat Galor, Kelly K Nichols, Noam A Cohen, Michelle Dalton
JournalThe ocular surface (Ocul Surf) Vol. 25 Pg. 58-64 (07 2022) ISSN: 1937-5913 [Electronic] United States
PMID35550851 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2022 Elsevier Inc. All rights reserved.
Chemical References
  • Receptors, Nicotinic
Topics
  • Dry Eye Syndromes
  • Humans
  • Lacrimal Apparatus (innervation)
  • Nociceptors
  • Receptors, Nicotinic
  • Tears

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: