Abstract |
Tear secretion is regulated by the lacrimal functional unit consisting of afferent and efferent nerve innervation. The afferent arm consists of trigeminal nociceptors on the ocular surface and nasal mucosa. When stimulated by agonists, nicotinic acetylcholine receptors on nerve endings in the nose initiate a reflex arc resulting in instantaneous tear secretion. Pharmacologic nasal neural stimulation to increase endogenous tear production is a novel approach to treating dry eye disease.
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Authors | Stephen C Pflugfelder, Austin Cao, Anat Galor, Kelly K Nichols, Noam A Cohen, Michelle Dalton |
Journal | The ocular surface
(Ocul Surf)
Vol. 25
Pg. 58-64
(07 2022)
ISSN: 1937-5913 [Electronic] United States |
PMID | 35550851
(Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2022 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Dry Eye Syndromes
- Humans
- Lacrimal Apparatus
(innervation)
- Nociceptors
- Receptors, Nicotinic
- Tears
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