Abstract | BACKGROUND: CASE PRESENTATION: We report nine patients diagnosed with thyroid eye disease whose intraocular pressure decreased during teprotumumab treatment for 8 weeks: patient 1, a 67-year-old Hispanic woman; patient 2, an 86-year-old African-American man; patient 3, a 71-year-old Caucasian woman; patient 4, a 72-year-old Hispanic woman; patient 5, a 65-year-old Caucasian woman; patient 6, a 54-year-old Caucasian man; patient 7, a 54-year-old Asian man; patient 8, a 31-year-old Asian woman; patient 9, a 60-year-old Caucasian woman. The diagnosis of thyroid eye disease was based on increased redness, swelling, and excessive tearing; abnormal proptosis, lid retraction, and diplopia measurements were also taken during physical examination. Intraocular pressure in primary, lateral gaze, and upgaze was documented. There was significant (p = 0.0397) improvement of primary gaze eye pressure from pre- teprotumumab infusions (baseline) to completion of the treatment course. CONCLUSIONS:
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Authors | Matthew Chu, Jonathan Sung, Michael Song, Alice Song, Julia Song |
Journal | Journal of medical case reports
(J Med Case Rep)
Vol. 16
Issue 1
Pg. 195
(May 10 2022)
ISSN: 1752-1947 [Electronic] England |
PMID | 35538553
(Publication Type: Case Reports, Journal Article)
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Copyright | © 2022. The Author(s). |
Chemical References |
- Antibodies, Monoclonal, Humanized
- teprotumumab
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antibodies, Monoclonal, Humanized
(therapeutic use)
- Exophthalmos
(drug therapy)
- Female
- Graves Ophthalmopathy
(diagnosis, drug therapy)
- Humans
- Intraocular Pressure
- Male
- Middle Aged
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