Comparison of the Effects of Latanoprostene Bunod and Timolol on Retinal Blood Vessel Density: A Randomized Clinical Trial.

Abstract

PURPOSE:

To compare the differences in retinal vessel density (VD) between topical administration of latanoprostene bunod (LBN) ophthalmic solution 0.024% and timolol maleate 0.5% in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT) and normal subjects.

DESIGN:

Randomized, single center, crossover clinical trial.

METHODS:

Eligible subjects were examined during 6 study visits over 12 weeks. All subjects were randomized in a 1:1 ratio to LBN dosed once daily or timolol dosed twice daily in both eyes (OU) for a duration of 4 weeks each, separated by a 2-week washout period. A comprehensive eye examination OU was performed at each visit. Testing was performed with optical coherence tomography and optical coherence tomography angiography (optic nerve and macula), as well as visual field examination, on the study eye at baseline and before and after each treatment.

RESULTS:

One eye from each of 50 patients was enrolled (10 healthy patients, 26 patients with OHT, and 14 patients with OAG). After administration of LBN there was significantly increased macular VD (0.76% [0.20%-1.33%], P = 0.009) and a trend in increasing peripapillary VD in patients with OAG and patients with OHT. In contrast, after administration of timolol, there were no differences in macular VD, and a decrease in peripapillary VD only was observed in the nasal inferior sector (-0.56% [-1.08% to -0.03%], P = .04) in patients with OAG and patients with OHT. No change in peripapillary or macular VD was observed in the normal subjects (P > .05 for all).

CONCLUSIONS:

Topical administration of LBN enhanced macular VD in patients with OAG or patients with OHT. In contrast, timolol administration did not have any effect on VD.

• Authors: Nevin W El-Nimri, Sasan Moghimi, Rafaella C Penteado, Elham Ghahari, Diya Yang, Nicole Brye, James Proudfoot, Jiun L Do, Andrew Camp, Matthew Salcedo, Veronica Rubio, Robert N Weinreb
• Journal: American journal of ophthalmology (Am J Ophthalmol) Vol. 241 Pg. 120-129 (09 2022) ISSN: 1879-1891 [Electronic] United States
• PMID: 35526590 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2022 Elsevier Inc. All rights reserved.

Chemical References

• BOL 303259-X
• Prostaglandins F, Synthetic
• Timolol

Topics

• Glaucoma, Open-Angle
• Humans
• Intraocular Pressure
• Macula Lutea
• Ocular Hypertension (drug therapy)
• Prostaglandins F, Synthetic
• Retinal Vessels
• Timolol (therapeutic use)
• Tomography, Optical Coherence