Abstract | BACKGROUND: METHODS: A single-center, retrospective review was performed for patients with STS treated with SLNB and/or lymphadenectomy from 1994 to 2018. Clinicopathologic characteristics, multimodality treatment, regional/distant recurrence-free survival (RFS), and overall survival (OS) were examined. RESULTS: Eighty-six patients underwent SLNB (n = 34) and/or lymphadenectomy (n = 60) for STS. The most frequent histologic subtypes were epithelioid, clear cell, and undifferentiated pleomorphic sarcoma. Eight of 34 (23.5%) patients had a positive SLNB with 5-year OS of 71.4% compared with 71.9% for those with a negative SLNB. Eight of the 26 SLN-negative patients (30.8%) eventually developed nodal recurrence (n = 2) and/or (n = 6) distant metastasis with an estimated 5-year OS of 50%. Of patients undergoing lymphadenectomy, estimated 5-year OS was 44.6% and median RFS was 12 months. Eight (13.3%) had distant disease at time of lymphadenectomy, 20 (33.3%) developed distant recurrence after lymphadenectomy, and 6 (10%) developed regional-only recurrence. Patients with regional-only recurrence after lymphadenectomy had an estimated 5-year OS of 66.7% compared with 29.1% for those who recurred distantly. CONCLUSIONS: Patients with positive SLNB had similar survival to those with negative SLNB. Lymphadenectomy for isolated nodal disease is associated with poor RFS but reasonable 5-year OS when recurrence is regional-only. In STS, regional disease appears clinically distinct from distant metastatic disease and has better outcomes.
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Authors | Russell G Witt, Brandon Cope, Derek J Erstad, Yi-Ju Chiang, Elise F Nassif, Christopher P Scally, Keila E Torres, Kelly K Hunt, Barry W Feig, Christina L Roland, Emily Z Keung |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 29
Issue 11
Pg. 7092-7100
(Oct 2022)
ISSN: 1534-4681 [Electronic] United States |
PMID | 35501583
(Publication Type: Journal Article)
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Copyright | © 2022. Society of Surgical Oncology. |
Topics |
- Humans
- Lymph Node Excision
- Lymphatic Metastasis
- Neoplasm Recurrence, Local
(pathology, surgery)
- Retrospective Studies
- Sarcoma
(surgery)
- Sentinel Lymph Node
(pathology)
- Sentinel Lymph Node Biopsy
- Skin Neoplasms
(pathology)
- Soft Tissue Neoplasms
(surgery)
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