Everyday function profiles in prodromal stages of MCI: Prospective cohort study.

Abstract

INTRODUCTION:

The nature and course of limitations in everyday function in the early clinical stages of cognitive decline is not well known.

METHODS:

We compared complex everyday functional profiles at baseline in 59 community-dwelling older individuals with normal cognitive performance who went on to develop incident mild cognitive impairment (MCI) ("pre-MCI") with 284 older individuals who remained cognitively normal over follow-up.

RESULTS:

The mean number of limitations on complex everyday function at baseline was 3.1 ± 3.0 in the 59 pre-MCI cases and 2.0 ± 2.4 in the 284 normal controls (P = .003). Pre-MCI cases had limitations in traveling, entertaining, remembering appointments, and hobbies compared to normal controls. A progressive increase in mild limitations on complex everyday function preceded the incidence of MCI (mean change: pre-MCI 1.9 ± 3.6 vs normal controls 0.5 ± 2.7, P < .001).

DISCUSSION:

Prodromal stages of MCI are associated with progressive mild limitations in complex activities of daily living.

• Authors: Joe Verghese, Pierfilippo De Sanctis, Emmeline Ayers
• Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association (Alzheimers Dement) Vol. 19 Issue 2 Pg. 498-506 (02 2023) ISSN: 1552-5279 [Electronic] United States
• PMID: 35472732 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: © 2022 the Alzheimer's Association.

Topics

• Humans
• Prospective Studies
• Activities of Daily Living (psychology)
• Prodromal Symptoms
• Cognitive Dysfunction (epidemiology)
• Cognition
• Neuropsychological Tests