Establishment of antitick efficacy of a phytoformulation prepared from Annona squamosa leaf extracts for the management of acaricide resistant tick infestations on cattle.
|
| Abstract |
To combat the problem of acaricide resistance in ticks, efforts have been made to develop eco-friendly herbal acaricides which are safe for animal use with no possibilities of evoking environment and residual toxicity. In the present study, the acaricidal properties of a commonly available plant, Annona squamosa have been established to develop a novel antitick phytoformulation using leaf extract, suitable solvents and emulsifier for managing resistant tick infestations in animals. The quality control of the safe and stable phytoformulation using Rutin as a major constituent was maintained by HPTLC profiling. Several phytformulations (A-E) were prepared and formulation 'C' is identifried as the most effective showing 52.5-75% antitick activity against in vitro treated resistant strains of R. microplus (IVRI-IV and V) with 33.8-40.2% inhibition of oviposition while 65-85% mortality against multiacaricide resistant field populations. The phytoformulation provided 70.4% efficacy after first larval challenge in experimentally infested animals. The field efficacy of the formulation in different multilocational field trials was 68.53-77.8%. The detail antitick efficacy of the formulation along with safety and stability are explained as a component of antitck technology to manage resistant tick problem in livestock.
|
|---|---|
| Authors | Anil Kumar Sharma, Shashi Shankar Tiwari, Sachin Kumar, Ajay Kumar Singh Rawat, Sharad Srivastava, Debdatta Ray, Nirbhay Kumar Singh, Sumer Singh Rawat, Arun Kumar Sangwan, Srikanta Ghosh |
| Journal | Acta tropica (Acta Trop) Vol. 233 Pg. 106463 (Sep 2022) ISSN: 1873-6254 [Electronic] Netherlands |
| PMID | 35460645 (Publication Type: Journal Article) |
| Copyright | Copyright © 2022. Published by Elsevier B.V. |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!