Bone marrow transplantation in a patient with myelodysplasia associated with diffuse eosinophilic fasciitis.

Abstract

A 34-year-old man with diffuse eosinophilic fasciitis and a hypocellular myelodysplastic syndrome underwent marrow transplantation from an HLA-identical brother. Prompt hematopoietic reconstitution was observed, strongly suggesting that the marrow hypocellularity was caused by neither a serum inhibitory factor nor a microenvironmental disorder. The patient died of disseminated cytomegalovirus infection too early to evaluate the impact of hematopoietic reconstitution on the eosinophilic fasciitis. Nevertheless, marrow transplantation may offer a therapeutic option for those patients with this disorder who develop severe hematopoietic dysfunction and who have a suitable marrow donor.

• Authors: M S Tallman, R W McGuffin, C S Higano, G Starkebaum, S J Collins, H Johnston, J W Singer, D J Perry, A Kunath
• Journal: American journal of hematology (Am J Hematol) Vol. 24 Issue 1 Pg. 93-9 (Jan 1987) ISSN: 0361-8609 [Print] United States
• PMID: 3541583 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• HLA Antigens

Topics

• Adult
• Bone Marrow Transplantation
• Eosinophilia (complications, pathology, surgery)
• Family
• Fasciitis (complications, pathology, surgery)
• HLA Antigens (analysis)
• Humans
• Male
• Myelodysplastic Syndromes (complications)
• Tissue Donors