Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: AIM OF THE STUDY: In this review,the pharmacokinetics and pharmacological activities of liquiritin have been summarized. MATERIALS AND METHODS: The information on liquiritin up to 2021 was collected from PubMed, Web of Science, Springer Link, and China National Knowledge Infrastructure databases. The key words were " liquiritin", "nerve", " tumor", "cardiac", etc. RESULTS: The absorption mechanism of liquiritin conforms to the passive diffusion and first-order kinetics while with low bioavailability. Liquiritin can penetrate the blood-brain-barrier. Besides, liquiritin displays numerous pharmacological effects including anti- Alzheimer's disease, antidepressant, antitumor, anti-inflammatory, cardiovascular protection, antitussive, hepatoprotection, and skin protective effects. In addition, the novel preparations, new pharmacological effects,and cdusafty of liquiritin are also discussed in this review. CONCLUSION: This review provides a comprehensive state of knowledge on the pharmacokinetics and pharmacological activities of liquiritin, and makes a forecast for its research directions and applications in clinic.
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Authors | Junyuan Qin, Junren Chen, Fu Peng, Chen Sun, Yu Lei, Guangru Chen, Gangming Li, Yanpeng Yin, Ziwei Lin, Liujun Wu, Jing Li, Wenxiu Liu, Cheng Peng, Xiaofang Xie |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 293
Pg. 115257
(Jul 15 2022)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 35395381
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2022 Elsevier B.V. All rights reserved. |
Chemical References |
- Drugs, Chinese Herbal
- Flavanones
- Glucosides
- liquiritin
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Topics |
- Drugs, Chinese Herbal
(chemistry, pharmacology, therapeutic use)
- Flavanones
(pharmacology)
- Glucosides
- Medicine, Chinese Traditional
|