Targeted delivery of maytansine to liver cancer cells via galactose-modified supramolecular two-dimensional glycomaterial.

Abstract

A two-dimensional (2D) glycomaterial for targeted delivery of maytansine to liver cancer cells was developed. Host-guest interaction between a galactosyl dye and human serum albumin (HSA) produces supramolecular galactoside-HSA conjugates, which are then used to coat 2D MoS2. The 2D glycomaterial was shown to be capable of the targeted delivery of maytansine to a liver cancer cell line that highly expresses a galactose receptor, resulting in greater cytotoxicity than maytansine alone.

• Authors: Hai-Na Xie, Yu-Yuan Chen, Guo-Biao Zhu, Hai-Hao Han, Xi-Le Hu, Zhi-Qiang Pan, Yi Zang, Dong-Hao Xie, Xiao-Peng He, Jia Li, Tony D James
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 58 Issue 32 Pg. 5029-5032 (Apr 19 2022) ISSN: 1364-548X [Electronic] England
• PMID: 35373789 (Publication Type: Journal Article)

Chemical References

• Maytansine
• Galactose
• Serum Albumin, Human

Topics

• Cell Line
• Cell Line, Tumor
• Galactose
• Humans
• Liver Neoplasms (drug therapy)
• Maytansine (pharmacology)
• Serum Albumin, Human