THE USE OF NEAR INFRARED SPECTROSCOPY IN ALKAPTONURIA - THE MISLEADING OCHRONOSIS - A CASE REPORT AND LITERATURE REVIEW.

Abstract

INTRODUCTION:

Near infrared spectroscopy is a non-invasive method to assess regional oxygenation and is being used in transcatheter aortic valve implantation to document periods of cerebral hypoperfusion, where cerebrovascular events are one of the most feared complications. Alkaptonuria is a rare metabolic disease characterized by accumulation of homogentisic acid in tissues and body fluids. The accumulation of pigment might interfere with the absorption of near infrared light, used in near infrared spectroscopy monitoring. We present a case of near infrared spectroscopy failing to accurately monitor cerebral oximetry in a woman, with alkaptonuria, undergoing a transcatheter aortic valve implantation.

• Authors: Carolina Mateus, Ana Filipa Carvalho, Ana Fonte Boa
• Journal: Portuguese journal of cardiac thoracic and vascular surgery (Port J Card Thorac Vasc Surg) Vol. 28 Issue 4 Pg. 47-49 (Jan 04 2022) ISSN: 2184-9927 [Print] Portugal
• PMID: 35334175 (Publication Type: Case Reports, Journal Article, Review)

Topics

• Alkaptonuria (diagnosis)
• Cerebrovascular Circulation
• Female
• Humans
• Ochronosis (diagnosis)
• Oximetry
• Spectroscopy, Near-Infrared