Effect of Hemocoagulase on the Prevention of Bleeding after Percutaneous Renal Biopsy.

Abstract

A percutaneous renal biopsy is an essential tool for the diagnosis of various renal diseases; however, post-biopsy bleeding is a major complication. Hemocoagulase is a detoxified and purified snake venom enzyme that is widely used to prevent post-procedural bleeding. In this study, we retrospectively analyzed the effect of hemocoagulase on post-renal biopsy bleeding. We included 221 patients who underwent percutaneous renal biopsy between April 2017 and December 2020 and analyzed post-renal biopsy hemoglobin (Hb) decline in patients who were administered a periprocedural hemocoagulase injection. After the renal biopsy, the mean Hb decrease in the entire patient cohort was 0.33 ± 0.84 g/dL. Periprocedural hemocoagulase injection lowered the Hb decline post-renal biopsy (0.50 ± 0.87 vs. 0.23 ± 0.80 g/dL, p = 0.0204). The propensity-matched cohort was also adjusted for factors influencing postprocedural bleeding; periprocedural hemocoagulase injection reduced the Hb decline post-renal biopsy (0.56 ± 0.89 vs. 0.17 ± 0.74 g/dL, p = 0.006). There were no adverse events (e.g., thrombosis and anaphylactic shock) due to hemocoagulase. Our study demonstrated the beneficial effect of hemocoagulase on post-renal biopsy Hb decline, suggesting its clinical value in preventing post-renal biopsy bleeding.

• Authors: Kenta Torigoe, Ayuko Yamashita, Shinichi Abe, Kumiko Muta, Hiroshi Mukae, Tomoya Nishino
• Journal: Toxins (Toxins (Basel)) Vol. 14 Issue 3 (03 18 2022) ISSN: 2072-6651 [Electronic] Switzerland
• PMID: 35324720 (Publication Type: Journal Article)

Chemical References

• Batroxobin

Topics

• Batroxobin (therapeutic use, toxicity)
• Biopsy
• Hemorrhage (chemically induced)
• Humans
• Retrospective Studies