Intertwined pathways of complement activation command the pathogenesis of lupus nephritis.

Abstract

The complement system is involved in the origin of autoimmunity and systemic lupus erythematosus. Both genetic deficiency of complement components and excessive activation are involved in primary and secondary renal diseases, including lupus nephritis. Among the pathways, the classical pathway has long been accepted as the main pathway of complement activation in systemic lupus erythematosus. However, more recent studies have shown the contribution of factors B and D which implies the involvement of the alternative pathway. While there is evidence on the role of the lectin pathway in systemic lupus erythematosus, it is yet to be demonstrated whether this pathway is protective or harmful in lupus nephritis. Complement is being explored for the development of disease biomarkers and therapeutic targeting. In the current review we discuss the involvement of complement in lupus nephritis.

• Authors: Abhigyan Satyam, Ryo Hisada, Rhea Bhargava, Maria G Tsokos, George C Tsokos
• Journal: Translational research : the journal of laboratory and clinical medicine (Transl Res) Vol. 245 Pg. 18-29 (07 2022) ISSN: 1878-1810 [Electronic] United States
• PMID: 35296451 (Publication Type: Journal Article, Review, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2022 Elsevier Inc. All rights reserved.

Chemical References

• Lectins
• Complement System Proteins

Topics

• Complement Activation (physiology)
• Complement System Proteins
• Humans
• Lectins
• Lupus Erythematosus, Systemic
• Lupus Nephritis (drug therapy)