Data on body mass, glucose tolerance and bone phenotype of mice with osteogenesis imperfecta on long-term low-fat and high-fat diets.

Abstract

Male and female mice with a dominant severe bone fragility disorder, osteogenesis imperfecta, and their wild-type littermates (FVB background) were challenged with a long-term (26 weeks) high-fat diet to evaluate the development of obesity and glucose intolerance. Here we present data for the measurements of body mass, the outcome of glucose tolerance tests during the long-term diet, as well as organ weights and bone phenotype at the end of the study. Interpretation of the data and further in-depth analysis can be found in the article "Male but not female mice with severe osteogenesis imperfecta are partially protected from high-fat diet-induced obesity." by Tauer JT, Boraschi-Diaz I, Al Rifai O, Rauch F, Ferron M, Komarova SV, published in Molecular Genetics and Metabolism. The data presented here demonstrate individual mouse outcomes of long-term diet experiments that can be reused for comparative studies of diet-induced changes in wild-type mice on different backgrounds and different mouse models of osteogenesis imperfecta.

• Authors: Josephine T Tauer, Iris Boraschi-Diaz, Svetlana V Komarova
• Journal: Data in brief (Data Brief) Vol. 41 Pg. 107961 (Apr 2022) ISSN: 2352-3409 [Electronic] Netherlands
• PMID: 35242941 (Publication Type: Journal Article)
• Copyright: © 2022 The Author(s). Published by Elsevier Inc.