Kimura Disease of the Thigh Treated With Surgical Excision and Dupilumab.

Abstract

ABSTRACT:

Kimura disease (KD) is a rare, chronic inflammatory disorder presenting with solitary or multiple masses. Treatment options include surgical excision, corticosteroids, and radiotherapy; however, optimal therapy remains to be established. Moreover, efficacy of a humanized monoclonal antibody, dupilumab (Dupixent), requires to be demonstrated. Here, we present a 36-year-old male patient with an enlarging mass in the left medial thigh and chronic eczema over the abdomen and lower legs. Kimura disease was diagnosed after surgical excision. Postoperative treatment with dupilumab was applied with an initial dose of 600 mg followed by 300 mg every 2 weeks for 8 months. No recurrence of KD was observed in the 1-year follow-up. The eczematous lesions improved greatly. To our knowledge, this is the first report of using dupilumab for treating KD.

• Authors: Hsuan-Yu Huang, Chin-Yi Yang, Wen-Teng Yao, Yu-Fan Chen, Chia-Meng Yu, Kwang-Yi Tung, Ming-Feng Tsai
• Journal: Annals of plastic surgery (Ann Plast Surg) Vol. 88 Issue 1s Suppl 1 Pg. S110-S113 (03 01 2022) ISSN: 1536-3708 [Electronic] United States
• PMID: 35225857 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• Antibodies, Monoclonal, Humanized
• dupilumab

Topics

• Adult
• Antibodies, Monoclonal, Humanized (therapeutic use)
• Humans
• Kimura Disease
• Male
• Thigh (surgery)
• Treatment Outcome