Clozapine in the treatment of tremor.

Abstract

In an open trial 25 tremor patients were treated with clozapine in small doses (18-75 mg per day). The effect was measured with a new movement analyzer. Nine of 12 essential tremor patients were greatly improved. In six of nine patients with Parkinson tremor and in two combined essential tremor/Parkinson tremor patients tremor almost disappeared. Sedation is a major side effect, but decreases in most patients with time. The risk of agranulocytosis makes blood control necessary.

• Authors: H Pakkenberg, B Pakkenberg
• Journal: Acta neurologica Scandinavica (Acta Neurol Scand) Vol. 73 Issue 3 Pg. 295-7 (Mar 1986) ISSN: 0001-6314 [Print] Denmark
• PMID: 3521185 (Publication Type: Clinical Trial, Comparative Study, Journal Article)

Chemical References

• Dibenzazepines
• Clozapine

Topics

• Alcoholism (physiopathology)
• Clinical Trials as Topic
• Clozapine (therapeutic use)
• Dibenzazepines (therapeutic use)
• Double-Blind Method
• Humans
• Parkinson Disease (drug therapy, physiopathology)
• Tremor (drug therapy, etiology, physiopathology)