Clinical Features of Untreated Type 2 Macular Telangiectasia and Efficacy of Anti-Vascular Endothelial Growth Factor Therapy in Macular Neovascularization

Abstract

Objectives:

To compare best corrected visual acuity (BCVA), central macular thickness (CMT), and central choroidal thickness (CCT) in patients with type 2 macular telangiectasia (MacTel 2) and a control group and to evaluate the efficacy of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment in MacTel 2 patients with macular neovascularization (MNV).

Materials and Methods:

We conducted a retrospective chart review of consecutive MacTel 2 patients who underwent a full ophthalmologic examination including BCVA and dilated fundus examination with slit-lamp biomicroscopy, fluorescein angiography, and optical coherence tomography imaging at baseline and follow-up visits. BCVA, CMT, and CCT were compared between all identified patients (n=26) and a control group (n=30). A subgroup analysis was performed among eyes with MNV (n=7) before and after treatment.

Results:

CMT and CCT were significantly lower in the MacTel 2 group compared to the control group. Forty-one treatment-naive eyes without MNV proliferation showed no significant change in BCVA, CMT, or CCT during follow-up. Eight eyes of 7 MacTel 2 patients developed MNV during follow-up. All of the patients were treated with intravitreal anti-VEGF.

Conclusion:

It is important to closely follow MacTel 2 patients for MNV development. To avoid adverse effects, we prefer to monitor patients who have not yet developed MNV. Patients with proliferative MacTel 2 with decreasing visual function may benefit from intravitreal anti-VEGF treatment.

• Authors: Müge Çoban Karataş, Gürsel Yılmaz, Aslıhan Yüce Sezen, Çağla Sarıtürk
• Journal: Turkish journal of ophthalmology (Turk J Ophthalmol) Vol. 52 Issue 1 Pg. 45-49 (02 23 2022) ISSN: 2149-8709 [Electronic] Turkey
• PMID: 35196839 (Publication Type: Journal Article)

Topics

• Diabetic Retinopathy (drug therapy)
• Fluorescein Angiography (methods)
• Humans
• Retrospective Studies
• Telangiectasis
• Visual Acuity