Abstract | BACKGROUND: OBJECTIVES: MATERIAL AND METHODS: The albino Wistar male rats were divided into 3 groups: healthy group (HG), only alloxan group (AXG) and alloxan+taxifolin group (ATG). Hyperglycemia in animals was caused through intraperitoneal injection of alloxan at a dose of 120 mg/kg. Paw pain thresholds of animals were measured using Basile algesimeter. Sciatic nerve tissues were examined biochemically and histopathologically in order to evaluate neuropathy. RESULTS: Our experimental results revealed that taxifolin significantly prevented the increase of plasma glucose concentration level with alloxan administration, the decrease of the paw pain threshold related to hyperglycemia, the change of oxidant- antioxidant balance in the sciatic nerve tissue in favor of oxidants, and the deterioration of tissue morphology in animals. CONCLUSIONS:
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Authors | Murat Alay, Miyase Gulcin Sonmez, Aysegul Sakin, Murat Atmaca, Halis Suleyman, Gulce Naz Yazici, Abdulkadir Coban, Bahadir Suleyman, Seval Bulut, Durdu Altuner |
Journal | Advances in clinical and experimental medicine : official organ Wroclaw Medical University
(Adv Clin Exp Med)
Vol. 31
Issue 4
Pg. 427-435
(Apr 2022)
ISSN: 1899-5276 [Print] Poland |
PMID | 35178903
(Publication Type: Journal Article)
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Chemical References |
- Antioxidants
- Reactive Oxygen Species
- Alloxan
- Quercetin
- taxifolin
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Topics |
- Alloxan
(pharmacology)
- Animals
- Antioxidants
(metabolism, pharmacology)
- Hyperglycemia
(complications, drug therapy)
- Male
- Neuralgia
(drug therapy)
- Oxidative Stress
- Quercetin
(analogs & derivatives)
- Rats
- Rats, Wistar
- Reactive Oxygen Species
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