Abstract | INTRODUCTION: METHODS: RESULTS: Eleven (68.75%) patients underwent CVVHDF and five (31.25%) underwent peritoneal dialysis. The median leucine reduction rate per hour was 2.56% (1.75-7.6) in the CVVHDF group, 0.78% (0.54-1.83) in the PD group, and was significantly higher in the CVVHDF group (p = 0.001). Posttreatment plasma leucine levels were found to be 198 (20-721) μmol/L in the CVVHDF group and 600 (250-967) μmol/L in the PD group, and CVVHDF was found to be significantly lower (p = 0.08). Complications such as hypotension, electrolyte imbalance, and filter obstruction occurred in the CVVHDF group. CONCLUSION: This study showed that CVVHDF is more effective than PD for rapidly eliminating elevated leucine levels caused by MSUD in the newborn and it is not associated with increased complication rates.
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Authors | İbrahim Deger, Muhittin Çelik, İbrahim Taş, Serhat Samancı |
Journal | Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
(Ther Apher Dial)
Vol. 26
Issue 3
Pg. 658-666
(Jun 2022)
ISSN: 1744-9987 [Electronic] Australia |
PMID | 35166449
(Publication Type: Journal Article)
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Copyright | © 2022 International Society for Apheresis and Japanese Society for Apheresis. |
Chemical References |
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Topics |
- Acute Kidney Injury
(therapy)
- Continuous Renal Replacement Therapy
- Female
- Hemodiafiltration
(adverse effects)
- Humans
- Infant, Newborn
- Leucine
- Male
- Maple Syrup Urine Disease
(complications, therapy)
- Retrospective Studies
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