Successful treatment of primary headache associated with sexual activity using erenumab: Case report.

Abstract

BACKGROUND:

Primary headache associated with sexual activity is a rare benign headache disorder that is provoked by sexual excitement. It is a diagnosis of exclusion after the underlying secondary causes have been ruled out. The cause of this headache disorder is still unknown. Cerebral vasospasm, pericranial muscular contraction, hemodynamic and respiratory changes during sexual activity are most commonly listed as possible pathophysiological mechanisms. Several acute and prophylactic options with good clinical response have been described in the case series.

CASE REPORT:

We present a case of a 30-year-old woman with primary headache associated with sexual activity and comorbid with frequent episodic migraine without aura. Both headache disorders were successfully managed with monoclonal antibody against calcitonine gene-related peptide (CGRP) receptor erenumab 70 mg.

CONCLUSION:

The efficacy of erenumab in our case presumes that CGRP might also be an important mediator in facilitating primary headache associated with sexual activity.

• Authors: Gytis Makarevičius, Kristina Ryliškienė
• Journal: Cephalalgia : an international journal of headache (Cephalalgia) Vol. 42 Issue 7 Pg. 680-683 (06 2022) ISSN: 1468-2982 [Electronic] England
• PMID: 35166159 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Monoclonal, Humanized
• Calcitonin Gene-Related Peptide Receptor Antagonists
• erenumab
• Calcitonin Gene-Related Peptide

Topics

• Adult
• Antibodies, Monoclonal, Humanized
• Calcitonin Gene-Related Peptide (therapeutic use)
• Calcitonin Gene-Related Peptide Receptor Antagonists (therapeutic use)
• Female
• Headache (drug therapy, etiology)
• Humans
• Migraine Disorders (complications, drug therapy, prevention & control)
• Sexual Behavior