Histological and immunohistochemical findings in a fatal case of thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination.
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| Abstract |
This case report describes a fatal case of a young woman with superior sagittal, transverse and sigmoid sinus thrombosis after administration of the ChAdOx1 nCov-19 vaccination. Eleven days post-vaccination she was found unconscious and transferred to the Emergency Department. Blood parameters showed low platelets, and a CT scan showed an extensive left intracranial hemorrhage and the presence of an occlusive thrombus of the superior sagittal sinus. She under-went a craniectomy, but after the intervention, she remained in a comatose state. After a few days, her clinical conditions worsened, and she died. A complete autopsy was performed which showed a thrombosis of the cerebral venous district, of the upper and lower limbs. A blood sample was also performed to carry out a gene study about the predisposition to thrombosis. The organ samples were studied through light microscope both in hematoxylin-eosin and immunohistochemical examination, and showed a strong inflammatory response in all samples and at the site of thrombosis. Our study aims to provide a proper autopsy technique to study the entire cerebral venous system through a multidisciplinary approach (anatomical dissection and neurosurgery) in post-vaccine venous thrombosis.
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| Authors | Cristoforo Pomara, Monica Salerno, Massimiliano Esposito, Francesco Sessa, Francesco Certo, Claudio Tripodo, Francesca Rappa, Giuseppe Maria Barbagallo |
| Journal | Pathology, research and practice (Pathol Res Pract) Vol. 231 Pg. 153796 (Mar 2022) ISSN: 1618-0631 [Electronic] Germany |
| PMID | 35144085 (Publication Type: Case Reports, Journal Article) |
| Copyright | Copyright © 2022 Elsevier GmbH. All rights reserved. |
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