Segmentectomy versus wedge resection for radiological solid predominant and low metabolic non-small cell lung cancer.

Abstract

OBJECTIVES:

The prognosis of segmentectomy and wedge resection for solid predominant early-stage non-small cell lung cancer with low metabolic activity is unclear.

METHODS:

This study aimed to assess patients who underwent segmentectomy or wedge resection with curative intent for clinically node-negative non-small cell lung cancer presenting as a solid predominant tumour (consolidation tumour ratio >50%) with a whole size ≤3 cm and [18F]-fluoro-2-deoxy-D-glucose accumulation weaker than that of the mediastinum tissue (Deauville score, 1 or 2) on positron emission tomography/computed tomography. The cumulative incidence of recurrence (CIR) was compared using the Gray method, and the predictive factor of CIR was analysed using the Fine and Gray method.

RESULTS:

Of 140 patients included in this study, 93 (66.4%) underwent segmentectomy and 47 (33.6%) underwent wedge resection. No significant difference in the clinical stage was found between the 2 groups. The CIR was higher with wedge resection than with segmentectomy (P = 0.004). Recurrence after wedge resection was noted in 4 (8.5%) patients, 2 of whom had a recurrent site containing lung parenchyma of the preserved lobe and hilum lymph node, which would have been resected if segmentectomy had been performed. In the multivariable analysis for CIR using inverse probability of treatment weighting and the procedure, wedge resection was a significantly worse predictive factor (hazard ratio, 12.280; P = 0.025).

CONCLUSIONS:

Segmentectomy rather than wedge resection should be considered for solid predominant, small-size non-small cell lung cancer even if [18F]-fluoro-2-deoxy-D-glucose accumulation is low.

• Authors: Atsushi Kagimoto, Yasuhiro Tsutani, Takahiro Mimae, Yoshihiro Miyata, Morihito Okada
• Journal: Interactive cardiovascular and thoracic surgery (Interact Cardiovasc Thorac Surg) Vol. 34 Issue 5 Pg. 814-821 (05 02 2022) ISSN: 1569-9285 [Electronic] England
• PMID: 35137087 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The Author(s) 2022. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery.

Chemical References

• Deoxyglucose

Topics

• Carcinoma, Non-Small-Cell Lung (diagnostic imaging, epidemiology, surgery)
• Deoxyglucose
• Humans
• Lung Neoplasms (diagnostic imaging, epidemiology, surgery)
• Neoplasm Staging
• Pneumonectomy (adverse effects, methods)
• Retrospective Studies
• Small Cell Lung Carcinoma (surgery)