Investigational spleen tyrosine kinase (SYK) inhibitors for the treatment of autoimmune diseases.

Abstract

INTRODUCTION:

Autoimmune diseases (ADs) are disorders induced by multiple inflammatory mediators, in which immune system attacks healthy tissues and triggers tissue injury. Targeted regulation of the activity of kinases that influence inflammation is one of the major therapies for ADs. Recently, investigational spleen tyrosine kinase (SYK) inhibitors have shown encouraging results in the AD therapy.

AREAS COVERED:

This article provides a background on autoimmune diseases and provides an update on investigational SYK inhibitors. This literature review was conducted by searching publications about investigational SYK inhibitors in the treatment of ADs from experimental to clinical studies. The search terms used were SYK inhibitors, R406, fostamatinib (R788), P505-15 (PRT062607), entospletinib (GS-9973), R112, lanraplenib (GS-9876), cerdulatinib, R343, BAY-61-3606, GSK compound 143 (GSK143), R211, SKI-G-618, SKI-O-85, ER-27319, YM193306, RO9021 in conjunction with autoimmune disease using electronic databases including PubMed, EMBASE, MEDLINE and Google Scholar.

EXPERT OPINION:

SYK inhibitors are promising drugs with unique advantages and acceptable tolerability and safety for the treatment of ADs. However, the difficulties in developing highly selective SYK inhibitors and the unknown effects are challenges. Long-term and real-world data are essential to determine the risk-benefit ratio and true role of SYK inhibitors in the therapy of ADs.

• Authors: Su'an Tang, Qinghong Yu, Changhai Ding
• Journal: Expert opinion on investigational drugs (Expert Opin Investig Drugs) Vol. 31 Issue 3 Pg. 291-303 (Mar 2022) ISSN: 1744-7658 [Electronic] England
• PMID: 35130124 (Publication Type: Journal Article, Review)

Chemical References

• Protein Kinase Inhibitors
• Protein-Tyrosine Kinases
• SYK protein, human
• Syk Kinase

Topics

• Autoimmune Diseases (drug therapy)
• Humans
• Protein Kinase Inhibitors (adverse effects)
• Protein-Tyrosine Kinases
• Syk Kinase