Abstract | BACKGROUND: PURPUSE: In this study, we aim to find out the active pharmacodynamic ingredients and reveal the treatment mechanism of active pharmacodynamic ingredients. METHODS: Based on the pharmacodynamic evaluation and chemomic profiling of BJG in COPD rats, an integrated multi-omics analysis was performed, including molecular networking, metabonomics, proteomics and bioinformatics. Moreover, focus on the active compounds, we verified the molecular core mechanism by molecular biology methods. RESULTS: CONCLUSION: In this study, our findings indicated that some compounds in BJG alleviates the pathological process of COPD, which is related to regulating lung function, mucus production, pulmonary embolism and energy metabolism and this will be a benefit complementary to GOLD guidelines.
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Authors | Hechen Wang, Yuanyuan Hou, Xiaoyao Ma, Linlin Cui, Yongrui Bao, Yang Xie, Suyun Li, Xiansheng Meng, Jiansheng Li, Gang Bai |
Journal | Phytomedicine : international journal of phytotherapy and phytopharmacology
(Phytomedicine)
Vol. 98
Pg. 153963
(Apr 2022)
ISSN: 1618-095X [Electronic] Germany |
PMID | 35121390
(Publication Type: Journal Article)
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Copyright | Copyright © 2022 Elsevier GmbH. All rights reserved. |