Association between prenatal exposure to ambient air pollutants and postpartum depressive symptoms: A multi-city cohort study.

Abstract

BACKGROUND:

Women are vulnerable to depression during postpartum period. While several studies have shown associations between ambient air pollution exposure and depression in general population, there was few studies focused on the effect of various air pollutants on postpartum depression (PPD).

OBJECTIVE:

This study is designed to explore the association between prenatal exposure to air pollutants and PPD, and to reveal the potential vulnerable exposure time point.

METHODS:

The study enrolled 10,209 pregnant women who delivered between October 2019 and February 2021 in 5 participating hospitals from 3 cities in China. Edinburgh Postnatal Depression Scale (EPDS) was administered at 6 weeks postpartum to identify PPD symptoms. Associations between PPD symptoms and exposure levels in PM2.5, PM10, SO2, CO, NO2, and O3 averaged over the whole pregnancy and each trimester were estimated using logistic regression models after adjusting for potential confounding factors. Distributed lag models (DLMs) were used to determine the relevant associations in each gestational week.

RESULTS:

The risk for developing PPD symptoms was significant following a 10 μg/m3 increase in PM10 (aOR = 1.47, 95%CI:1.36-1.59), NO2 (aOR = 1.63, 95%CI:1.44-1.85), and 0.1 mg/m3 increase in CO (aOR = 2.31, 95%CI: 1.99-2.69) during the whole pregnancy. Similar results were also found in exposure during each trimester of pregnancy. Besides, SO2 exposure during the second trimester was a major risk factor for developing PPD symptoms (aOR = 1.10, 95%CI:1.03-1.18). Consistent effects were also observed in DLMs, except for PM2.5 and O3, which showed no significant sensitive windows throughout pregnancy period.

CONCLUSION:

Exposure to PM10, CO, NO2, and SO2 in pregnancy is associated with increased risks of developing depression at 6 weeks postpartum. Our findings reveal the importance of air pollution control for preventing maternal mental health disorders among the public.

• Authors: Chen-Chi Duan, Cheng Li, Jing-Jing Xu, Yi-Chen He, Hua-Lin Xu, Dan Zhang, Jia-Qi Yang, Jia-Le Yu, Wan-Ting Zeng, Ying Wang, Lei Chen, Cindy-Lee Dennis, Yan-Ting Wu, He-Feng Huang
• Journal: Environmental research (Environ Res) Vol. 209 Pg. 112786 (06 2022) ISSN: 1096-0953 [Electronic] Netherlands
• PMID: 35077713 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Chemical References

• Air Pollutants
• Environmental Pollutants
• Particulate Matter

Topics

• Air Pollutants (analysis, toxicity)
• Air Pollution (adverse effects, analysis)
• China (epidemiology)
• Cities (epidemiology)
• Cohort Studies
• Depression
• Environmental Pollutants
• Female
• Humans
• Particulate Matter (analysis, toxicity)
• Postpartum Period
• Pregnancy
• Prenatal Exposure Delayed Effects