The Effect of Improving Preoperative Sleep Quality on Perioperative Pain by Zolpidem in Patients Undergoing Laparoscopic Colorectal Surgery: A Prospective, Randomized Study.

Abstract

METHODS:

A prospective, randomized study was conducted with 88 patients undergoing laparoscopic colorectal surgery. The experimental group (S group, n = 44) was given 10 mg of zolpidem tartrate one night before the surgical procedure, while no medication was given to the control group (C group, n = 44). The primary outcome was the intraoperative remifentanil consumption. Sufentanil consumption, average patient-controlled analgesia (PCA) effective press times, the visual analog scale (VAS) scores, and incidences of postoperative nausea and vomiting (PONV) were recorded at 6 h (T1), 12 h (T2), and 24 h (T3) postoperatively.

RESULTS:

The intraoperative remifentanil consumption was significantly lower in the S group than that in the C group (p < 0.01). Sufentanil consumption at 6 h and 12 h postoperatively was significantly lower in the S group than that in the C group (p < 0.05); average PCA effective press times and VAS scores, at 6 h and 12 h postoperatively, were significantly lower in the S group than those in the C group (p < 0.01); differences between groups 24 h postoperatively were not significant. No significant between-group difference was noted in the incidence of nausea and vomiting.

CONCLUSION:

Improving patients' sleep quality the night before surgical procedure by zolpidem can decrease the usage of intraoperative analgesics and reduce postoperative pain.

• Authors: Zhennan Xiao, Bo Long, Zeji Zhao
• Journal: Pain research & management (Pain Res Manag) Vol. 2022 Pg. 3154780 ( 2022) ISSN: 1918-1523 [Electronic] United States
• PMID: 35069955 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2022 Zhennan Xiao et al.

Chemical References

• Analgesics, Opioid
• Zolpidem

Topics

• Analgesia, Patient-Controlled (methods)
• Analgesics, Opioid (therapeutic use)
• Colorectal Surgery
• Double-Blind Method
• Humans
• Laparoscopy (adverse effects, methods)
• Pain, Postoperative (drug therapy, epidemiology, etiology)
• Prospective Studies
• Sleep Quality
• Zolpidem (therapeutic use)