Abstract | PURPOSE: METHODS AND MATERIALS: In this retrospective study, absolute lymphocyte counts (ALC) of 66 patients were obtained before, during, and after CCRT. Persistent lymphopenia was defined as ALC < 500/μL at 3 months after CCRT. The impact of regional dose on lymphocyte depletion and recovery was investigated using voxel-based analysis (VBA). RESULTS: Most patients (n = 65) experienced lymphopenia during CCRT: 39 patients (59.0%) had grade (G) 3+ lymphopenia. Fifty-nine patients (89.3%) recovered from treatment-related lymphopenia at 3 months after CCRT, whereas 7 (10.6%) showed persistent lymphopenia. Patient characteristics associated with persistent lymphopenia were older age and ALC before and during treatment. In multivariable Cox regression analysis, recovery from lymphopenia was identified as a significant prognostic factor for Progression Free Survival (HR 0.35, 95% CI 0.13-0.93, p = 0.034) and Overall Survival (HR 0.24, 95% CI 0.08-0.68, p = 0.007). Voxel-based analysis showed strong correlation of dose to the upper mediastinum with lymphopenia at the end of CCRT, but not at 3 months after CCRT. CONCLUSION: Recovery from lymphopenia is strongly correlated to improved survival of patients undergoing CCRT and adjuvant immunotherapy, and is correlated to lymphocyte counts pre- and post-CCRT. VBA reveals high correlation of dose to large vessels to lymphopenia at the end of CCRT. Therefore, efforts should be made not only for preventing lymphocyte depletion during CCRT but also for helping lymphocyte recovery after CCRT.
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Authors | Yeona Cho, Yejin Kim, Ibrahim Chamseddine, Won Hee Lee, Hye Ryun Kim, Ik Jae Lee, Min Hee Hong, Byung Chul Cho, Chang Geol Lee, Seungryong Cho, Jin Sung Kim, Hong In Yoon, Clemens Grassberger |
Journal | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
(Radiother Oncol)
Vol. 168
Pg. 1-7
(03 2022)
ISSN: 1879-0887 [Electronic] Ireland |
PMID | 35033601
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2022 Elsevier B.V. All rights reserved. |
Topics |
- Carcinoma, Non-Small-Cell Lung
(therapy)
- Chemoradiotherapy
(adverse effects)
- Humans
- Immunotherapy
(adverse effects)
- Lung Neoplasms
(radiotherapy)
- Lymphocytes
- Lymphopenia
(chemically induced)
- Retrospective Studies
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