Pro: Oximes should be used routinely in organophosphate poisoning.

Abstract

In poisoning with organophosphorus compounds (OP), patients can only profit from the regeneration of acetylcholinesterase, when the poison load has dropped below a toxic level. Every measure that allows an increase of synaptic acetylcholinesterase (AChE) activity at the earliest is essential for timely termination of the cholinergic crisis. Only drug-induced reactivation allows fast restoration of the inhibited AChE. Obidoxime and pralidoxime have proved to be able to reactivate inhibited cholinesterase thereby saving life of poisoned animals. A plasma level of obidoxime or pralidoxime allowing reactivation in humans poisoned by OP can be adjusted. There is no doubt that obidoxime and pralidoxime are able to reactivate OP-inhibited AChE activity in poisoned patients, thereby increasing AChE activity and contributing substantially to terminate cholinergic crisis. Hence, a benefit may be expected when substantial reactivation is achieved. A test system allowing determination of red blood cell AChE activity, reactivatability, inhibitory equivalents and butyrylcholinesterase activity is available for relatively low cost. If any reactivation is possible while inhibiting equivalents are present, oxime therapy should be maintained. In particular, when balancing the benefit risk assessment, obidoxime or palidoxime should be given as soon as possible and as long as a substantial reactivation may be expected.

• Authors: Horst Thiermann, Franz Worek
• Journal: British journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 88 Issue 12 Pg. 5064-5069 (12 2022) ISSN: 1365-2125 [Electronic] England
• PMID: 35023196 (Publication Type: Journal Article)
• Copyright: © 2022 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.

Chemical References

• pralidoxime
• Oximes
• Obidoxime Chloride
• Acetylcholinesterase
• Cholinesterase Reactivators
• Butyrylcholinesterase
• Cholinesterase Inhibitors

Topics

• Humans
• Animals
• Organophosphate Poisoning (drug therapy)
• Oximes (therapeutic use)
• Obidoxime Chloride (pharmacology, therapeutic use)
• Acetylcholinesterase
• Cholinesterase Reactivators (therapeutic use, pharmacology)
• Butyrylcholinesterase
• Cholinesterase Inhibitors