Vincristine induced fever in a child with embryonal rhadbomyosarcoma.

Abstract

INTRODUCTION:

Febrile episodes in oncology is common are mostly of infectious etiology requiring repeated investigations and escalation of antibiotics. But, drug induced fever occur more often than we think in oncological set-up.

CASE REPORT:

A 5 year old male child with rhabdomyosarcoma, developed high grade fever spikes following Vincristine monotherapy. Infective etiology work up was negative and the fever responded to corticosteroids.

MANAGEMENT AND OUTCOME:

He was treated with corticosteroids as premedication considering vincristine induced fever. The further courses of VCR- monotherapy were uneventful with steroids as premedication.

DISCUSSION:

We present the case of vincristine induced fever in a child with embryonal rhabdomyosarcoma. Clinician's should consider drug induced fever at appropriate conditions, to avoid leading to antibiotic resistance.

• Authors: Dr Arul Janani, Dr Anandkumar Shruthilaya, Dr Jayaraman Dhaarani, Dr Scott X Julius
• Journal: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (J Oncol Pharm Pract) Vol. 28 Issue 5 Pg. 1209-1210 (Jul 2022) ISSN: 1477-092X [Electronic] England
• PMID: 35018851 (Publication Type: Case Reports, Journal Article)

Chemical References

• Vincristine
• Anti-Bacterial Agents

Topics

• Male
• Child
• Humans
• Child, Preschool
• Vincristine (adverse effects)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects)
• Rhabdomyosarcoma (therapy)
• Fever (chemically induced, drug therapy)
• Anti-Bacterial Agents (therapeutic use)