Alcoholic fatty liver disease (AFLD) is a common chronic
liver disease and has become a critical global public health problem.
Green tea is a popular drink worldwide and contains several bioactive compounds. Different
green teas could contain diverse compounds and possess distinct bioactivities. In the present study, the effects of 10
green teas on chronic alcohol induced-
fatty liver disease in mice were explored and compared. The results showed that several
green teas significantly reduced
triacylglycerol levels in serum and liver as well as the
aminotransferase activities in mice at a dose of 200 mg/kg, suggesting that they possess hepatoprotective effects. Moreover, several
green teas remarkably decreased the expression of
cytochrome P450 2E1, the levels of
malondialdehyde and
4-hydroxynonenoic acid, and the contents of proinflammatory
cytokines, indicating that they could alleviate oxidation damage and
inflammation induced by chronic alcohol exposure. In addition, Seven Star Matcha
Tea and
Selenium-Enriched Matcha
Tea could increase
glutathione level. Furthermore, the main
phytochemical components in
green teas were determined and quantified by high-performance liquid chromatography, and the correlation analysis showed that
gallic acid,
gallocatechin,
catechin,
chlorogenic acid, and
epigallocatechin gallate might at least partially contribute to protective effects on AFLD. In conclusion,
Selenium-Enriched Chaoqing
Green Tea, Xihu Longjing
Tea, Taiping Houkui
Tea, and
Selenium-Enriched Matcha
Tea showed the strongest preventive effects on AFLD. This research also provides the public with new insights about the effects of different
green teas on AFLD.