Abstract | OBJECTIVES: MATERIALS AND METHODS:
Solvent casting technique was used to formulate the ODF formed by natural hydrophilic polymers matrix of hydroxypropyl methylcellulose E15 and pullulan. Propylene glycol as plasticizing agent imparted satisfactory tenacity and flexibility to ODFs. Fourier transform infrared spectroscopy studies were performed to investigate any potential compatibility, and the results revealed no potential interaction between fluoxetine and excipients. Developed ODFs were evaluated for physicochemical properties, content uniformity, in vitro disintegration time, and in vitro dissolution time studies. Results: The experimental data. RESULTS: The experimental data suggested that different polymer concentrations had a complex effect on content uniformity, in vitro disintegration time, and cumulative percentage drug release from the ODFs. TF7 was the most optimized formulation with a disintegration time of 10.66 sec and 99.37% drug release within 3 min. Additionally, the most optimized fluoxetine ODF was submitted to a Universal Testing Machine for tensile strength and percentage elongation determination. It was also further evaluated by thermogravimetric analysis, scanning electron microscopy and X-ray diffraction. CONCLUSION:
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Authors | Haseeb Anwar Dad, Asra Shanzeh Shabbir, Saman Ali, Tariq Mahmood |
Journal | Turkish journal of pharmaceutical sciences
(Turk J Pharm Sci)
Vol. 18
Issue 6
Pg. 683-694
(Dec 31 2021)
ISSN: 2148-6247 [Electronic] Turkey |
PMID | 34978397
(Publication Type: Journal Article)
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