The efficacy of trimetazidine in non-ischemic heart failure patients: a meta-analysis of randomized controlled trials.

Abstract

Trimetazidine has been reported to benefit patients with heart failure (HF) and angina. The impact of trimetazidine on non-ischemic HF remains unclear. We reviewed clinical trials to investigate whether trimetazidine could improve exercise endurance, life quality, and heart function in non-ischemic HF patients. We searched the Cochrane Central Register of Controlled Trials, EMBASE, PubMed, and Web of science for randomized clinical trials published before April 30th, 2020; Studies limited to patients with non-ischemic HF, aged ≥18 years, comparing trimetazidine with conventional therapy with/without placebo. Outcome measurements included primary outcomes (6 minutes walking test (6-MWT)) and secondary outcomes (life quality scores, echocardiography parameters, biomarker, peak oxygen consumption). The follow-up period was longer than three months. This study was registered with international prospective register of systematic reviews (PROSPERO) (CRD42020182982). Six studies with 310 cases were included in this research. Trimetazidine significantly improved 6-MWT (weighted mean difference (WMD) = 48.51 m, 95% confidence interval (CI) [29.41, 67.61], p < 0.0001, I2 = 0%), left ventricle ejection fraction (LVEF) (WMD = 3.09%, 95% CI [1.09, 5.01], p = 0.002, I2 = 0%) at 3 months, and LVEF (WMD = 6.09%, 95% CI [3.76, 8.42], p < 0.0001, I2 = 12%) at 6 months. Furthermore, it reduced peak oxygen consumption (WMD = -2.24 mL/kg per minute, 95% CI [-4.09, -0.93], p = 0.02). This meta-analysis suggested that trimetazidine might be an effective strategy for improving exercise endurance and cardiac function in patients with non-ischemic HF.

• Authors: Chengchen Zhao, Chunna Jin, Xiaopeng He, Meixiang Xiang
• Journal: Reviews in cardiovascular medicine (Rev Cardiovasc Med) Vol. 22 Issue 4 Pg. 1451-1459 (Dec 22 2021) ISSN: 1530-6550 [Print] Singapore
• PMID: 34957784 (Publication Type: Journal Article, Meta-Analysis)
• Copyright: © 2021 The Author(s). Published by IMR Press.

Chemical References

• Vasodilator Agents
• Trimetazidine

Topics

• Adolescent
• Adult
• Heart Failure (diagnosis, drug therapy)
• Humans
• Randomized Controlled Trials as Topic
• Treatment Outcome
• Trimetazidine (adverse effects)
• Vasodilator Agents (adverse effects)