Abstract | Introduction: Methods: A case-control study was carried out between March 2018 and September 2019. Cases and controls were evaluated through the following scales: Hospital Anxiety Depression Scale ( HADS); Clinical Global Impression (CGI); Patient Global Impression of Improvement (PGI-I); Antidepressant Adverse Events checklist (AES). Results: A significant difference between the two groups of patients emerged at T1 in the HADS-A (p = 0.004) score and in the CGI score (p = 0.01), due to a major improvement in patients with a nutraceutical co-prescription. At T3 a significant statistical difference emerged, showing a greater improvement at HADS-D in the case group (p = 0.006), confirmed by a higher remission rate in patients taking a nutraceutical co-prescription. No differences in terms of adverse events emerged. Conclusion: This study shows promising data about the role of nutraceuticals as adjunctive treatment in major depressive disorder to improve SSRIs efficacy, with good tolerability. More data are needed to confirm these results, particularly about the role of nutraceuticals to decrease the latency of SSRIs response.
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Authors | Marta Ielmini, Ivano Caselli, Francesca Ceccon, Marcello Diurni, Nicola Poloni, Camilla Callegari |
Journal | Psychopharmacology bulletin
(Psychopharmacol Bull)
Vol. 51
Issue 4
Pg. 31-39
(11 03 2021)
ISSN: 2472-2448 [Electronic] United States |
PMID | 34887597
(Publication Type: Journal Article)
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Copyright | Copyright © 1964–2021 by MedWorks Media Inc, Los Angeles, CA All rights reserved. Printed in the United States. |
Chemical References |
- Serotonin Uptake Inhibitors
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Topics |
- Adult
- Case-Control Studies
- Depressive Disorder, Major
(drug therapy)
- Dietary Supplements
- Humans
- Quality of Life
- Selective Serotonin Reuptake Inhibitors
(therapeutic use)
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