Abstract | SCOPE:
Folic acid supplementation during pregnancy may lead to an imbalance when vitamin B12 intake is low ( folate trap) and may affect child's growth. METHODS: The authors study the association between third trimester maternal intakes of folate and B12 and birthweight and postnatal growth of 2632 infants from the KOALA Birth Cohort Study. Plasma vitamin biomarkers are measured in 1219 women. RESULTS: Imbalanced total intakes ( folate > 430 µg day-1 combined with B12 < 5.5 µg day-1 ) are not associated with birthweight [β adj (95% CI) = -14.87 (-68.87, 39.13)] compared with high intakes of both. Imbalanced intake is associated with a lower z score of weight at 1-2 years [β adj = -0.14 (-0.25, -0.03)]. Having red blood cell folate > 745 nmol L-1 and plasma B12 < 172 pmol L-1 is not associated with birthweight [β adj = -7.10 (-97.90, 83.71) g]. Maternal dietary B12 intake [β adj = -9.5 (-15.6, -3.3)] and plasma methylmalonic acid [β adj = 234 (43, 426)] are associated with birthweight. CONCLUSION:
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Authors | Rima Obeid, Simone J P M Eussen, Monique Mommers, Luc Smits, Carel Thijs |
Journal | Molecular nutrition & food research
(Mol Nutr Food Res)
Vol. 66
Issue 2
Pg. e2100662
(01 2022)
ISSN: 1613-4133 [Electronic] Germany |
PMID | 34821015
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2021 The Authors. Molecular Nutrition & Food Research published by Wiley-VCH GmbH. |
Chemical References |
- Homocysteine
- Folic Acid
- Vitamin B 12
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Topics |
- Birth Weight
- Cohort Studies
- Female
- Folic Acid
(administration & dosage, metabolism)
- Homocysteine
- Humans
- Infant
- Infant, Newborn
- Pregnancy
- Pregnancy Trimester, Third
- Vitamin B 12
(administration & dosage, metabolism)
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