Abstract | OBJECTIVE: To evaluate the efficacy of keishibukuryogan, a traditional Kampo formula known to be an anti-Oketsu (impaired microcirculation and non-physiological blood congestion) drug, in combination with an anti-oxidant for the treatment of varicoceles. METHODS: We retrospectively analyzed 119 patients with palpable and subclinical varicoceles who were treated with 7.5 g/day of keishibukuryogan and 600 mg/day of tocopherol nicotinate. Their motile sperm concentrations at the start of medication and after 3 months were compared. As a subgroup analysis, a comparison test was carried out between patients with a high-grade varicocele and those with a low-grade varicocele. RESULTS: The mean age of the study patients was 35.6 years. Among them, 17, 41, 44 and 17 had subclinical, grade 1, grade 2 and grade 3 varicoceles, respectively. Overall, the differences in motile sperm concentration (millions/mL) before and after treatment were not significant (median 0.58, 95% confidence interval -0.12 to 1.56; P = 0.115). The results of the subgroup analysis showed that the motile sperm concentration in patients with a low-grade varicocele significantly increased (median 1.21, 95% confidence interval 0.45-2.47; P = 0.024); however, no significant improvements were seen in patients with a high-grade varicocele. CONCLUSIONS:
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Authors | Teppei Takeshima, Jurii Karibe, Tomoki Saito, Yukari Ishibashi, Kimitsugu Usui, Kohei Mori, Shinnosuke Kuroda, Mitsuru Komeya, Yasushi Yumura |
Journal | International journal of urology : official journal of the Japanese Urological Association
(Int J Urol)
Vol. 29
Issue 2
Pg. 165-169
(Feb 2022)
ISSN: 1442-2042 [Electronic] Australia |
PMID | 34818687
(Publication Type: Journal Article)
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Copyright | © 2021 The Japanese Urological Association. |
Chemical References |
- Drugs, Chinese Herbal
- keishibukuryogan
- Niacin
- Tocopherols
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Topics |
- Adult
- Drugs, Chinese Herbal
- Humans
- Infertility, Male
(drug therapy)
- Male
- Niacin
- Retrospective Studies
- Spermatozoa
- Tocopherols
- Varicocele
(drug therapy)
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