Reverse Genetics and Its Usage in the Development of Vaccine Against Poultry Diseases.

Abstract

Vaccines are the most effective and economic way of combating poultry viruses. However, the use of traditional live-attenuated poultry vaccines has problems such as antigenic differences with the currently circulating strains of viruses and the risk of reversion to virulence. In veterinary medicine, reverse genetics is applied to solve these problems by developing genotype-matched vaccines, better attenuated and effective live vaccines, broad-spectrum vaccine vectors, bivalent vaccines, and genetically tagged recombinant vaccines that facilitate the serological differentiation of vaccinated animals from infected animals. In this chapter, we discuss reverse genetics as a tool for the development of recombinant vaccines against economically devastating poultry viruses.

• Authors: Barnali Nath, Sudhir Morla, Sachin Kumar
• Journal: Methods in molecular biology (Clifton, N.J.) (Methods Mol Biol) Vol. 2411 Pg. 77-92 ( 2022) ISSN: 1940-6029 [Electronic] United States
• PMID: 34816399 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Chemical References

• Antibodies, Viral
• Vaccines, Attenuated
• Vaccines, Synthetic
• Viral Vaccines

Topics

• Animals
• Antibodies, Viral (immunology)
• Chickens (immunology)
• Poultry (immunology)
• Poultry Diseases (immunology, prevention & control)
• Reverse Genetics (methods)
• Vaccines, Attenuated (immunology)
• Vaccines, Synthetic (genetics, immunology)
• Viral Vaccines (genetics, immunology)