Acute Ischemia of Lower Extremities Caused by Ergotamine Toxicity due to Pharmacologic Interaction With Cobicistat in an HIV-Positive Patient.

Abstract

Ergotism is an uncommon condition that affects patients with exposure to ergot alkaloids causing ischemia of extremities. We report the case of lower extremities ischemia caused by ergot toxicity in a human immunodeficiency virus (HIV) positive individual due to the interaction between ergot alkaloid and Cobicistat. In addition, we present a brief review of medical, and pharmacological aspects of this condition. To our knowledge, this is the second reported case describing this interaction.

• Authors: Núria Hostench-Junoy, Mauricio Ramírez-Montoya, Bahaa Arefai-Refai, JorgeDel Estal-Jiménez, Zebenzuí José Santana-Rodríguez, Laura Costa-Pérez
• Journal: Annals of vascular surgery (Ann Vasc Surg) Vol. 80 Pg. 392.e1-392.e6 (Mar 2022) ISSN: 1615-5947 [Electronic] Netherlands
• PMID: 34775015 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2021. Published by Elsevier Inc.

Chemical References

• Adrenergic alpha-1 Receptor Agonists
• Anti-HIV Agents
• Cobicistat
• Ergotamine

Topics

• Adrenergic alpha-1 Receptor Agonists (adverse effects)
• Anti-HIV Agents (adverse effects)
• Cobicistat (adverse effects)
• Drug Interactions
• Ergotamine (adverse effects)
• Ergotism (diagnosis, etiology)
• HIV Infections (complications, drug therapy)
• Humans
• Ischemia (chemically induced)
• Lower Extremity (blood supply)
• Male
• Migraine Disorders (drug therapy)
• Young Adult