Relationships Between Placental Lipid Activated/Transport-Related Factors and Macrosomia in Healthy Pregnancy.

Abstract

To assess associations between infants with macrosomia and placental expression levels of lipid activated/transport-related factors and umbilical cord blood lipid concentrations in healthy pregnancy. We conducted a case-control study of 38 macrosomic neonates (MS group) and 39 normal-birth-weight newborns (NC group) in a healthy pregnancy. Cord blood lipid levels were measured by automatic biochemical analyzer, mRNA and protein expression levels of placental lipid activated/transport-related factors were determined by real-time polymerase chain reaction and western blot, respectively. Compared with NC group, cord blood total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), and non-esterified fatty acid (NEFA) concentrations were decreased in the MS group. The mRNA and protein expression levels of placental peroxisome proliferator-activated receptors (PPARα, PPARγ), plasma membrane fatty acid-binding protein (FABPpm), and fatty acid translocase (FAT/CD36) were significantly higher in the MS group than the NC group. And there was a weak positive correlation between the expression of PPARγ, FABP4, and FABP3 mRNA in the placenta and the HDLC (rs = 0.439; P = 0.005), NEFA (rs = 0.342; P = 0.041), and TG (rs = 0.349; P = 0.034) levels in the cord blood in the MS group, respectively. After multivariate adjustment, the logistic regression analysis showed that high placental PPARα (adjusted odds ratio [AOR] = 3.022; 95% confidence interval [CI] 1.032-8.853) and FAT/CD36 (AOR=2.989; 95%CI 1.029-8.679) and low LDLC concentration in the cord blood (AOR=0.246; 95%CI 0.080-0.759) increased the risk of macrosomia. The increased PPARα and FAT/CD36 expression levels may influence the occurrence of fetal macrosomia through regulating placental lipid transport.

• Authors: Li-Fang Ni, Ying Han, Chen-Chen Wang, Yan Ye, Miao-Miao Ding, Tian Zheng, Yu-Huan Wang, Hong-Tao Yan, Xin-Jun Yang
• Journal: Reproductive sciences (Thousand Oaks, Calif.) (Reprod Sci) Vol. 29 Issue 3 Pg. 904-914 (03 2022) ISSN: 1933-7205 [Electronic] United States
• PMID: 34750770 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2021. Society for Reproductive Investigation.

Chemical References

• Fatty Acid Transport Proteins

Topics

• Adult
• Case-Control Studies
• Fatty Acid Transport Proteins (blood)
• Female
• Fetal Blood (metabolism)
• Fetal Macrosomia (metabolism)
• Humans
• Infant, Newborn
• Placenta (metabolism)
• Pregnancy