Metabolic alkalosis following mitral valvuloplasty in a dog with preoperative acute kidney injury.

Abstract

CASE DESCRIPTION:

An 11-year-old sexually intact male Shih Tzu diagnosed with acute kidney injury and left-sided congestive heart failure that had nonelective mitral valve surgery.

CLINICAL FINDINGS:

Metabolic alkalosis developed postoperatively, and plasma bicarbonate concentration peaked 2 days after surgery (40.2 mmol/L; pH, 7.550).

TREATMENT AND OUTCOME:

Acetazolamide administration increased the urinary excretion of bicarbonate and contributed to the improvement of the dog's acid-base status and oxygenation capacity. Metabolic alkalosis persisted for 4 days after surgery, and no treatment was required after resolution. Plasma urea nitrogen and creatinine concentrations normalized 2 days after surgery.

CLINICAL RELEVANCE:

Severe metabolic alkalosis can occur as a complication following mitral valve surgery. Acetazolamide may be suitable for the treatment of severe metabolic alkalosis.

• Authors: Katsuhiro Matsuura, Tomohiko Yoshida, Takuya Uehara, Shusaku Yamada, Hideki Yotsuida, Mizuki Hasegawa, Sakie Katayose, Kurumi Yamada, Youta Yaginuma
• Journal: Journal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 259 Issue 11 Pg. 1332-1336 (11 01 2021) ISSN: 1943-569X [Electronic] United States
• PMID: 34727063 (Publication Type: Case Reports, Journal Article)

Chemical References

• Bicarbonates
• Acetazolamide

Topics

• Acetazolamide (therapeutic use)
• Acute Kidney Injury (etiology, therapy, veterinary)
• Alkalosis (etiology, veterinary)
• Animals
• Bicarbonates (therapeutic use)
• Dog Diseases (drug therapy, etiology)
• Dogs
• Hydrogen-Ion Concentration
• Male