Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: This article reviews the relevant literature and serves as a White Paper on collagen hydrolyzates and ultrahydrolyzates as emerging supplements often advertised to support joint health in OA. Collagen hydrolyzates have demonstrated some evidence of efficacy in a handful of small scale clinical trials, but their ability to treat and reverse advanced joint disease remains highly speculative, as is the case for other nutritional supplements. The aim of this White Paper is to stimulate research and development of collagen-based supplements for patients with OA and other musculoskeletal diseases at academic and industrial levels. This White Paper does not make any treatment recommendations for OA patients in the clinical context, but simply aims to highlight opportunities for scientific innovation and interdisciplinary collaboration, which are crucial for the development of novel products and nutritional interventions based on the best available and published evidence.
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Authors | Ali Mobasheri, Armaghan Mahmoudian, Ursule Kalvaityte, Ilona Uzieliene, Christina E Larder, Michèle M Iskandar, Stan Kubow, Paulo Cesar Hamdan, Cyro Scala de Almeida Jr, Lacey J Favazzo, Luc J C van Loon, Pieter J Emans, Pérola G Plapler, Michael J Zuscik |
Journal | Current rheumatology reports
(Curr Rheumatol Rep)
Vol. 23
Issue 11
Pg. 78
(10 30 2021)
ISSN: 1534-6307 [Electronic] United States |
PMID | 34716494
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Copyright | © 2021. The Author(s). |
Chemical References |
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Topics |
- Collagen
- Dietary Supplements
- Humans
- Joint Diseases
- Osteoarthritis
(drug therapy)
- Pain
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